Lithoplocamia lithistoides
Web21 jan. 2024 · Kahalalide F has displayed potent cytotoxicity against cancer cells of the breast (BT-474, MCF7, MDA-231, and SK-BR-3), colon (HT29 and LoVo), liver (Hep G2), lung adenocarcinoma (A549), ovaries,... Web10 jul. 2013 · Paclitaxel is arguably the most well-known and commercially successful mitosis inhibitor; intriguingly, these new compounds isolated from the Madagascan sponge Lithoplocamia lithistoides show a distinct biochemical mechanism of …
Lithoplocamia lithistoides
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WebAn Lithoplocamia lithistoides in uska species han Porifera nga ginhulagway ni Arthur Dendy hadton 1922. An Lithoplocamia lithistoides in nahilalakip ha genus nga … Web1 dec. 2015 · PM050489 is a tubulin-binding agent originally isolated from the marine sponge Lithoplocamia lithistoides. This compound binds with very high affinity to β-tubulin at a new site, disrupting the microtubule network and impairing its function during divison, which leads to mitotic aberrations.
Web11 dec. 2024 · At difference with the above cited phase II anticancer drugs, plocabulin (PM060184) is not an ADC but it is a Lithoplocamia lithistoides sponge-derived polyketide which acts as a very potent antimitotic agent, binding to a specific β-tubulin site with possible activity on tumors resistant to other tubulin inhibitors .
WebLithoplocamia is een geslacht van sponsdieren uit de klasse van de Demospongiae . For faster navigation, this Iframe is preloading the Wikiwand page for Lithoplocamia . Home Web21 jul. 2024 · Sponge: Lithoplocamia lithistoides PM060184 C 31H 45N 3O 7 Inhibits tubulin polymerization, which reduces microtubule dynamicity, and inhibits cell migration (),,,, Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential ...
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WebLithoplocamia lithistoides is 'n sponsspesie in die taksonomiese indeling van die Demospongiae . Die liggaam van die spons bestaan uit kieselnaalde en sponginevesels en is in staat om baie water op te neem. gutter and downspout manufacturersWebde Voogd, N.J.; Alvarez, B.; Boury-Esnault, N.; Carballo, J.L.; Cárdenas, P.; Díaz, M.-C.; Dohrmann, M.; Downey, R.; Hajdu, E.; Hooper, J.N.A.; Kelly, M.; Klautau ... gutter and downspout repair forest hill txWebThese compounds were active against one or more drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, vancomycin-resistant Enterococci, multidrug-resistant Mycobacterium tuberculosis, and amphotericin B-resistant Candida albicans. box with flowersWeb17 mrt. 2024 · Plocabulin (PM060184/PM184, PharmaMar) is a compound of marine origin derived from the Madagascan sponge Lithoplocamia lithistoides. Plocabulin belongs to a family of tubulin-binding agents that inhibits tubulin polymerization by binding to the dimer’s end, with one of the highest known affinities among tubulin-binding agents. box with flapWebOvarian cancer (OC) is a life-threatening tumor and the deadliest among gynecological cancers in developed countries. First line treatment with a carboplatin/paclitaxel regime is initially... box with fragileWebLithoplocamia lithistoides. Lithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili Raspailiidae. Nama ilmiah spesies ini pertama kali diterbitkan pada tahun 1922 oleh Dendy. Seperti spons pada umumnya, spesies ini memiliki tubuh … gutter and downspout repair fort worth txWeb1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. … box with flowers and chocolates